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The histone core domain evolves at single-residue resolution to directly orchestrate transcription

Summary: Nucleosomes are thought to be structural barriers to transcription, establishing a restrictive ground state that must be destabilized for gene expression. However, structural insights have revealed that transcription can proceed in the presence of nucleosomes, suggesting that this model is...

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Auteurs principaux: Zachary H. Harvey, Kathryn M. Stevens, Jian Yi Kok, Akihisa Osakabe, Jiaying Liu, Tobias Warnecke, Frédéric Berger
Format: Artigo
Langue:Inglês
Publié: Elsevier 2025-08-01
Collection:Cell Reports
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Accès en ligne:http://www.sciencedirect.com/science/article/pii/S2211124725008502
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