Lactate dehydrogenase A (LDHA)-mediated lactate generation promotes pulmonary vascular remodeling in pulmonary hypertension

Abstract Background High levels of lactate are positively associated with prognosis and mortality in pulmonary hypertension (PH). Lactate dehydrogenase A (LDHA) is a key enzyme for the production of lactate. This study is undertaken to investigate the role and molecular mechanisms of lactate and LDH...

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Autors principals:	Daiqian Wu, Shuo Wang, Fengxian Wang, Qing Zhang, Zhen Zhang, Xingbing Li
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2024-08-01
Col·lecció:	Journal of Translational Medicine
Matèries:	Pulmonary hypertension Lactate Lactate dehydrogenase A Vascular remodeling Glycolysis
Accés en línia:	https://doi.org/10.1186/s12967-024-05543-7
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