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Ex vivo and computational investigation of corneal iontophoresis to enhance penetration of high-molecular-weight compounds: a study using albumin as a model molecule

Abstract Efficient ocular drug delivery remains a major challenge due to the strong barrier properties of the corneal epithelium and the rapid clearance of topically applied formulations. This limitation is particularly critical for hydrophilic and high-molecular-weight (HMW) therapeutics such as pr...

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Principais autores: Asmaa K. Mohamed, Sherif S. Mahmoud, Shaimaa M. Elshibly, Gehan M. Kamal
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-03-01
Serier:Scientific Reports
Fag:
Cornea
Iontophoresis
Albumin
FTIR spectroscopy
Temperature modeling
Macromolecular delivery
Online adgang:https://doi.org/10.1038/s41598-026-43580-y
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