An aptamer-drug conjugate for promising cancer therapy with comprehensive evaluation from rodents to non-human primates

Abstract Aptamers serve as unique targeting ligands, making aptamer-drug conjugates (ApDCs) an attractive strategy for targeted cancer therapy. This study performs a comprehensive evaluation from rodents to non-human primates (NHP) of a protein tyrosine kinase 7 (PTK7)-targeted ApDC (Sgc8c-M) made b...

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Autores principales:	Minhui Su, Yuan Liu, Hongxin Lin, Xiaoxing Wang, Danxia Ying, Lizhuan Zhang, Cai Yang, Mengyuan Jiang, Lujuan Xu, Xie Wang, Yang Sun, Haiyan Xu, Ziwen Zhang, Xiaojia Wang, Ting Fu, Sitao Xie, Jiaxuan He, Xiangsheng Liu, Weihong Tan
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Publishing Group 2025-09-01
Colección:	Signal Transduction and Targeted Therapy
Acceso en línea:	https://doi.org/10.1038/s41392-025-02399-1
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