The DNA mismatch repair protein, MSH6 is a novel regulator of PD-L1 expression

Immune checkpoint inhibitors (ICIs) are extremely effective in a subgroup of mismatch repair-deficient (MMRd) cancers, but ∼50% remain resistant to treatment. We have shown for the first time that this may be due to the differential regulation of factors linked to response to ICIs upon loss of the d...

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Principais autores:	Kirsten Brooksbank, Charlotte Smith, Eleni Maniati, Amy Gibson, Wai Yiu Tse, Amy Kate Hall, Jun Wang, Tyson V Sharp, Sarah A Martin
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2025-09-01
סדרה:	Neoplasia: An International Journal for Oncology Research
נושאים:	Mismatch repair MSH6 Transcription factor PD-L1 Immunotherapy
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S1476558625000879
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