In Vivo Inhibition of Marek’s Disease Virus in Transgenic Chickens Expressing Cas9 and gRNA against ICP4

Marek’s disease (MD), caused by MD herpesvirus (MDV), is an economically important disease in chickens. The efficacy of the existing vaccines against evolving virulent stains may become limited and necessitates the development of novel antiviral strategies to protect poultry from MDV strains with in...

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Autori principali:	Arjun Challagulla, Kristie A. Jenkins, Terri E. O’Neil, Shunning Shi, Kirsten R. Morris, Terry G. Wise, Prasad N. Paradkar, Mark L. Tizard, Timothy J. Doran, Karel A. Schat
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2021-01-01
Serie:	Microorganisms
Soggetti:	Marek’s disease virus CRISPR/Cas9 ICP4 transgenic chicken disease resilience
Accesso online:	https://www.mdpi.com/2076-2607/9/1/164
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