Development and validation of a method for determination of Eculizumab concentration in human plasma by biolayer interferometry

The article describes a new method for measurement of monoclonal antibody Eculizumab concentration in human plasma in a range of 3-250 μg/ml. In this method we used an antibody Fab fragment, capable of binding to eculizumab specifically in human plasma. The method uses the biolayer interferometry fo...

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Autors principals:	V. M. Simonov, M. S. Pantushenko, A. A. Kazarov, O. A. Markova, G. N. Poroshin
Format:	Artigo
Idioma:	Russo
Publicat:	Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2018-02-01
Col·lecció:	Биопрепараты: Профилактика, диагностика, лечение
Matèries:	моноклональное антитело экулизумаб биослойная интерферометрия валидация monoclonal antibody eculizumab biolayer interferometry validation
Accés en línia:	https://www.biopreparations.ru/jour/article/view/98
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