Periodontitis-induced neuroinflammation triggers IFITM3-Aβ axis to cause alzheimer’s disease-like pathology and cognitive decline

Abstract Background Periodontitis is a risk factor linked to Alzheimer’s disease (AD), and characterized by amyloid-beta (Aβ) pathology. Mounting evidence suggests a contributory role of periodontitis in the onset and progression of AD. Type I interferons are upregulated in Porphyromonas gingivalis...

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Principais autores:	Lingwenyao Kong, Juanjuan Li, Lu Gao, Yonggang Zhao, Weixian Chen, Xumeng Wang, Songlin Wang, Fu Wang
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-07-01
Serija:	Alzheimer’s Research & Therapy
Teme:	Periodontitis Innate immunity Neuroinflammation IFITM3 Cognitive decline Alzheimer’s disease
Online dostop:	https://doi.org/10.1186/s13195-025-01818-3
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