NRF2 supports non-small cell lung cancer growth independently of CBP/p300-enhanced glutathione synthesis

Abstract Nuclear factor erythroid 2-related factor 2 (NRF2) is a stress responsive transcription factor that is mutationally activated in a subset (~25%) of clinically-aggressive non-small cell lung cancers (NSCLC). Mechanistic insight into drivers of the NRF2 dependency remains poorly understood. H...

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Päätekijät:	Ryan J Conrad, James A Mondo, Mike Lingjue Wang, Peter S Liu, Zijuan Lai, Feroza K Choudhury, Qingling Li, Weng Ruh Wong, James Lee, Frances Shanahan, Eva Lin, Scott Martin, Joachim Rudolph, John G Moffat, Dewakar Sangaraju, Wendy Sandoval, Timothy Sterne-Weiler, Scott A Foster
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Springer Nature 2025-05-01
Sarja:	EMBO Reports
Aiheet:	NRF2 CBP/p300 Non-small Cell Lung Cancer Glutathione ROS
Linkit:	https://doi.org/10.1038/s44319-025-00463-z
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