A Novel Small Molecule Neurotrophin-3 Analogue Promotes Inner Ear Neurite Outgrowth and Synaptogenesis In vitro

Sensorineural hearing loss is irreversible and is associated with the loss of spiral ganglion neurons (SGNs) and sensory hair cells within the inner ear. Improving spiral ganglion neuron (SGN) survival, neurite outgrowth, and synaptogenesis could lead to significant gains for hearing-impaired patien...

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Principais autores:	Judith S. Kempfle, Marlon V. Duro, Andrea Zhang, Carolina D. Amador, Richard Kuang, Ryan Lu, Boris A. Kashemirov, Albert S. Edge, Charles E. McKenna, David H. Jung
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-07-01
coleção:	Frontiers in Cellular Neuroscience
Assuntos:	inner ear regeneration synaptopathy neurotrophin-3 bisphosphonate small molecule
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fncel.2021.666706/full
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