TRIM16 controls turnover of protein aggregates by modulating NRF2, ubiquitin system, and autophagy: implication for tumorigenesis

Protein misfolding and protein aggregation are linked to several diseases commonly called as proteinopathies, which include cancer. Understanding the mechanisms of proteostasis could provide newer strategies to combat proteinopathies. We have recently demonstrated a new mechanism where we found that...

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Detalles Bibliográficos

Autores principales:	Kautilya Kumar Jena, Srinivasa Prasad Kolapalli, Subhash Mehto, Swati Chauhan, Santosh Chauhan
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis Group 2018-11-01
Colección:	Molecular & Cellular Oncology
Materias:	trim16 nrf2/nfe2l2 p62/sqstm1 autophagy. protein aggregates cancer oxidative stress protein homeostasis protein quality control aggrephagy proteotoxic stress
Acceso en línea:	http://dx.doi.org/10.1080/23723556.2018.1532251
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