Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis

The heart switches its energy substrate from glucose to fatty acids at birth, and maternal hyperglycemia is associated with congenital heart disease. However, little is known about how blood glucose impacts heart formation. Using a chemically defined human pluripotent stem-cell-derived cardiomyocyte...

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主要な著者:	Haruko Nakano, Itsunari Minami, Daniel Braas, Herman Pappoe, Xiuju Wu, Addelynn Sagadevan, Laurent Vergnes, Kai Fu, Marco Morselli, Christopher Dunham, Xueqin Ding, Adam Z Stieg, James K Gimzewski, Matteo Pellegrini, Peter M Clark, Karen Reue, Aldons J Lusis, Bernard Ribalet, Siavash K Kurdistani, Heather Christofk, Norio Nakatsuji, Atsushi Nakano
フォーマット:	Artigo
言語:	Inglês
出版事項:	eLife Sciences Publications Ltd 2017-12-01
シリーズ:	eLife
主題:	human pluripotent stem cell diabetes cardiac
オンライン･アクセス:	https://elifesciences.org/articles/29330
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