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Alterations in DNA methylation machinery in a rat model of osteoarthritis of the hip

Abstract Background This study aimed to validate alterations in the gene expression of DNA methylation-related enzymes and global methylation in the peripheral blood mononuclear cell (PBMC) and synovial tissues of animal hip osteoarthritis (OA) models. Methods Animals were assigned to the control (n...

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Principais autores: Yuya Kawarai, Junichi Nakamura, Shigeo Hagiwara, Miyako Suzuki-Narita, Kazuhide Inage, Seiji Ohtori
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-06-01
Serier:Journal of Orthopaedic Surgery and Research
Fag:
Hip osteoarthritis
Rat MIA-induced OA model
Epigenetics
DNA methylation
Online adgang:https://doi.org/10.1186/s13018-024-04847-0
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