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(-)-Syringaresinol Exerts an Antidepressant-like Activity in Mice by Noncompetitive Inhibition of the Serotonin Transporter

Background: <i>Albizia julibrissin</i> Durazz. is one of the most popular herbs used for depression treatment, but the molecular basis for its mechanism of action has not been fully addressed. Previously, we isolated and identified two lignan glycoside derivatives that were shown to noncompetitively...

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Principais autores: Yingyao Wu, Jianxin Cai, Hanhe Liu, Chan Li, Qingfa Tang, Yuan-Wei Zhang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-12-01
Serier:Pharmaceuticals
Fag:
(-)-syringaresinol
lignans
serotonin transporter
noncompetitive inhibitor
allosteric inhibition
antidepressants
Online adgang:https://www.mdpi.com/1424-8247/17/12/1637
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