Dys-regulated phosphatidylserine externalization as a cell intrinsic immune escape mechanism in cancer

Abstract The negatively charged aminophospholipid, phosphatidylserine (PS), is typically restricted to the inner leaflet of the plasma membrane under normal, healthy physiological conditions. PS is irreversibly externalized during apoptosis, where it serves as a signal for elimination by efferocytos...

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Detalhes bibliográficos

Principais autores:	Rachael Pulica, Ahmed Aquib, Christopher Varsanyi, Varsha Gadiyar, Ziren Wang, Trevor Frederick, David C. Calianese, Bhumik Patel, Kenneth Vergel de Dios, Victor Poalasin, Mariana S. De Lorenzo, Sergei V. Kotenko, Yi Wu, Aizen Yang, Alok Choudhary, Ganapathy Sriram, Raymond B. Birge
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-03-01
Colecção:	Cell Communication and Signaling
Assuntos:	Phosphatidylserine P4 ATPase Scramblases PS receptors Immune escape
Acesso em linha:	https://doi.org/10.1186/s12964-025-02090-6
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