The tumor suppressor NDRG2 promotes ACC1 proteasomal degradation and inhibits de novo lipogenesis in hepatocellular carcinoma
Abstract Hepatocellular carcinoma (HCC) is a malignant tumor characterized by high metabolic dependence. In particular, it relies on dysregulated lipid synthesis. N-myc downstream regulated gene 2 (NDRG2) acts as a tumor suppressor in HCC, yet its underlying mechanisms remain unclear. This study aim...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer
2026-04-01
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| Serie: | Molecular Biomedicine |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1186/s43556-026-00451-2 |
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