A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement

A recurrent theme in viral immune evasion is the sabotage of MHC-I antigen presentation, which brings virus the concomitant issue of ‘missing-self’ recognition by NK cells that use inhibitory receptors to detect surface MHC-I proteins. Here, we report that rodent herpesvirus Peru (RHVP) encodes a Qa...

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Автори:	Xiaoli Wang, Sytse J Piersma, Christopher A Nelson, Ya-Nan Dai, Ted Christensen, Eric Lazear, Liping Yang, Marjolein Sluijter, Thorbald van Hall, Ted H Hansen, Wayne M Yokoyama, Daved H Fremont
Формат:	Artigo
Мова:	Inglês
Опубліковано:	eLife Sciences Publications Ltd 2018-12-01
Серія:	eLife
Предмети:	viral immune evasion NK cell receptor non-classical MHC protein missing-self recognition herpesvirus
Онлайн доступ:	https://elifesciences.org/articles/38667
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