Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools.
The Saccharomyces cerevisiae Dun1 protein kinase is a downstream target of the conserved Mec1-Rad53 checkpoint pathway. Dun1 regulates dNTP pools during an unperturbed cell cycle and after DNA damage by modulating the activity of ribonucleotide reductase (RNR) by multiple mechanisms, including phosp...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science (PLoS)
2011-05-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3088718?pdf=render |
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