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Spironolactone and Fibrosis in Heart Failure Risk: Machine Learning Analysis of HOMAGE Trial Plasma Proteomics

ABSTRACT In the HOMAGE (Heart Omics in AGEing) trial, spironolactone reduced serum concentrations of procollagen Type I C‐terminal propeptide (PICP), a fibrosis biomarker, in patients at risk of heart failure. To elucidate the underlying mechanisms, multidimensional analyses including proteomics wer...

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Автори: Susana Ravassa, Nicolas Girerd, Frank Edelman, Begoña López, João Pedro Ferreira, Daniela Zurkan, Gorka San José, Iñigo Latasa, Pierpaolo Pellicori, Franco Cosmi, Johannes Petutschnigg, Stephane Heymans, Hans‐Peter Brunner‐La Rocca, Burkert Pieske, Christian Delles, Andrew L. Clark, Javier Díez, Faiez Zannad, John G. F. Cleland, Arantxa González, the HOMAGE Trial Committees and Investigators
Формат: Artigo
Мова:Inglês
Опубліковано: Wiley 2026-03-01
Серія:MedComm
Предмети:
biomarkers
fibrosis
heart failure
machine learning algorithms (MLA)
procollagen Type I C‐terminal propeptide (PICP)
spironolactone
Онлайн доступ:https://doi.org/10.1002/mco2.70634
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