Betulinic Acid Derivative BA5, Attenuates Inflammation and Fibrosis in Experimental Chronic Chagas Disease Cardiomyopathy by Inducing IL-10 and M2 Polarization

Chronic Chagas disease cardiomyopathy (CCC) is a major cause of heart disease in Latin America and treatment for this condition is unsatisfactory. Here we investigated the effects of BA5, an amide semi-synthetic derivative betulinic acid, in a model of CCC. Mice chronically infected with T. cruzi we...

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Principais autores:	Cássio Santana Meira, Emanuelle De Souza Santos, Renan Fernandes do Espírito Santo, Juliana Fraga Vasconcelos, Iasmim Diniz Orge, Carolina Kymie Vasques Nonaka, Breno Cardim Barreto, Alex Cleber Improta Caria, Daniela Nascimento Silva, José Maria Barbosa-Filho, Simone Garcia Macambira, Diogo Rodrigo Magalhães Moreira, Milena Botelho Pereira Soares
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-06-01
coleção:	Frontiers in Immunology
Assuntos:	Trypanosoma cruzi betulinic acid derivative immunomodulation chagas disease cardiomyopathy
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01257/full
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