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Predicting the Pharmacokinetics of T‐Cell Engagers as a Function of Target‐Mediated Drug Disposition

ABSTRACT T‐Cell Engagers (TCEs) are biological multi‐specific molecules designed to co‐engage targets on T cells and on a target cell for destruction. Molecular formats are typically derived from IgG monoclonal antibodies or similar fusion proteins with FcRn‐mediated recycling, such as albumin binde...

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Main Authors: Mark Penney, Alberto Ippolito, Elisa Fevola, Scott Rata, Liam Brown, Pablo Morentin Gutierrez, Rhys D. O. Jones
Format: Artigo
Language:Inglês
Published: Wiley 2025-11-01
Series:Clinical and Translational Science
Subjects:
pharmacokinetic modeling
pharmacokinetic prediction
pharmacokinetics
target‐mediated drug disposition
T‐cell engagers
Online Access:https://doi.org/10.1111/cts.70384
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