Measurements, Thermodynamic Modeling, and a Hydrogen Bonding Study on the Solubilities of Metoprolol Succinate in Organic Solvents

The solubilities of metoprolol succinate (a cardioselective β1 adrenergic receptor) in methanol, ethanol, n-propanol, isopropanol, n-butanol, ethyl acetate, and acetone were measured at temperatures ranging from (278.2 to 318.2) K using a solid–liquid equilibrium method. The solubility of...

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Auteurs principaux:	Jian Shen, Xianrui Liang, Hao Lei
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2018-09-01
Collection:	Molecules
Sujets:	metoprolol succinate solubility dissolution enthalpy hydrogen bonding thermodynamic model
Accès en ligne:	http://www.mdpi.com/1420-3049/23/10/2469
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