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TOMBU and COMBU as Novel Uronium-Type Peptide Coupling Reagents Derived from Oxyma-B

Here we describe two novel uronium salts, TOMBU and COMBU, derived from the recently described Oxyma-B for use in peptide bond synthesis. These coupling reagents are more stable than COMU in DMF. Furthermore, using various peptide synthetic models in solution and solid-phase synthesis, we reveal tha...

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Bibliografische Detailangaben
Hauptverfasser: Yahya E. Jad, Sherine N. Khattab, Beatriz G. de la Torre, Thavendran Govender, Hendrik G. Kruger, Ayman El-Faham, Fernando Albericio
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2014-11-01
Schriftenreihe:Molecules
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Online-Zugang:http://www.mdpi.com/1420-3049/19/11/18953
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