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Phase 1 first-in-human dose-escalation study of ANV419 in patients with relapsed/refractory advanced solid tumors

Background ANV419 is a stable antibody–cytokine fusion protein consisting of interleukin-2 (IL-2) fused to an anti-IL-2 monoclonal antibody that sterically hinders binding of IL-2 to the α subunit of its receptor but has selective affinity for the receptor βγ subunits. Thus, ANV419 preferentially st...

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Egile Nagusiak: Markus Joerger, Emiliano Calvo, Heinz Läubli, Juanita Lopez, Elena Garralda, Dagmar Hess, Elena Corral de la Fuente, Christoph Bucher, Guzman Alonso, Sangeeta Jethwa, David König, Vicky Sanchez Perez
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BMJ Publishing Group 2023-11-01
Saila:Journal for ImmunoTherapy of Cancer
Sarrera elektronikoa:https://jitc.bmj.com/content/11/11/e007784.full
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