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Bumetanide Effects on Resting-State EEG in Tuberous Sclerosis Complex in Relation to Clinical Outcome: An Open-Label Study

Neuronal excitation-inhibition (E/I) imbalances are considered an important pathophysiological mechanism in neurodevelopmental disorders. Preclinical studies on tuberous sclerosis complex (TSC), suggest that altered chloride homeostasis may impair GABAergic inhibition and thereby E/I-balance regulat...

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Principais autores: Erika L. Juarez-Martinez, Dorinde M. van Andel, Jan J. Sprengers, Arthur-Ervin Avramiea, Bob Oranje, Floortje E. Scheepers, Floor E. Jansen, Huibert D. Mansvelder, Klaus Linkenkaer-Hansen, Hilgo Bruining
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
coleção:Frontiers in Neuroscience
Assuntos:
tuberous sclerosis complex (TSC)
bumetanide
EEG
excitation-inhibition balance
repetitive behavior
irritability
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fnins.2022.879451/full
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