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Recombinant Live Attenuated Influenza Vaccine Viruses Carrying Conserved T Cell Epitopes of Human Adenoviruses Induce Functional Cytotoxic T Cell Responses and Protect Mice against both Infections

Human adenoviruses (AdVs) are one of the most common causes of acute respiratory viral infections worldwide. Multiple AdV serotypes with low cross-reactivity circulate in the human population, making the development of an effective vaccine very challenging. In the current study, we designed a cross-...

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Principais autores: Irina Isakova-Sivak, Victoria Matyushenko, Ekaterina Stepanova, Anastasia Matushkina, Tatiana Kotomina, Daria Mezhenskaya, Polina Prokopenko, Igor Kudryavtsev, Pavel Kopeykin, Konstantin Sivak, Larisa Rudenko
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-04-01
Serier:Vaccines
Fag:
human adenovirus
live attenuated influenza vaccine
viral vector
conserved epitopes
T cell-based vaccine
bivalent vaccine
Online adgang:https://www.mdpi.com/2076-393X/8/2/196
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