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Novel N-phenyl-2-(aniline) benzamide hydrochloride salt development for colon cancer therapy

IntroductionN-phenyl-2-(aniline) analog N53 is a previously discovered dual inhibitor of Topo I and COX-2, which exhibited significant anti-colon cancer activity in vitro, but the poor solubility and moderate anti-cancer activity in vivo hindered its further development.MethodsTo rectify the subopti...

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Kaydedildi:
Asıl Yazarlar: Yan Peng, Ying Peng, Wei Zhang, Siyi Zhang, Huiqian Peng, Zhen Li, Bo Li, Linyi Liu, Linsheng Zhuo, Zhen Wang, Junbo Wu, Weifan Jiang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2024-10-01
Seri Bilgileri:Frontiers in Pharmacology
Konular:
hydrochloride
water solubility
pharmacokinetic properties
Topo I and COX-2 dual inhibitor
anti-colon cancer activity
Online Erişim:https://www.frontiersin.org/articles/10.3389/fphar.2024.1452904/full
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