Discovery of selective ACAT2 antagonist via a combination strategy based on deep docking, pharmacophore modelling, and molecular dynamics simulation

Acyl-CoA: cholesterol acyltransferase (ACAT), a pivotal enzyme in the absorption and metabolism of cholesterol, is primarily responsible for intracellular esterification. ACAT inhibition is expected to diminish plasma lipid levels by impeding intestinal cholesterol absorption, thereby preventing the...

Olles dieđut

Bibliográfalaš dieđut

Váldodahkkit:	Yanfeng Liu, Feng Ding, Liangying Deng, Shuran Zhang, Lixing Wu, Huangjin Tong
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Taylor & Francis Group 2024-12-01
Ráidu:	Journal of Enzyme Inhibition and Medicinal Chemistry
Fáttát:	acyl-CoA: cholesterol acyltransferase selective inhibitors deep docking pharmacophore modelling molecular dynamics simulation
Liŋkkat:	https://www.tandfonline.com/doi/10.1080/14756366.2024.2403736
Fáddágilkorat:	Lasit fáddágilkoriid Eai fáddágilkorat, Lasit vuosttaš fáddágilkora!