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Deletion of gE in Herpes Simplex Virus 1 Leads to Increased Extracellular Virus Production and Augmented Interferon Alpha Production by Peripheral Blood Mononuclear Cells

Herpes simplex virus (HSV) in humans and pseudorabies virus (PRV) in pigs are both alphaherpesviruses. Plasmacytoid dendritic cells (pDCs) make part of the peripheral blood mononuclear cells (PBMCs) and are specialized in producing large amounts of antiviral type I interferon (IFN-I). IFN-I producti...

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Principais autores: Manon Claeys, Jonas Delva, Cedric Jacqmotte, Cliff Van Waesberghe, Herman W. Favoreel
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-12-01
Serier:Pathogens
Fag:
HSV-1
glycoprotein E
type I interferon
peripheral blood mononuclear cells
plasmacytoid dendritic cell
Online adgang:https://www.mdpi.com/2076-0817/13/12/1138
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