Knockdown of Inhibitory Guanine Nucleotide Binding Protein Giα‐2 by Antisense Oligodeoxynucleotides Attenuates the Development of Hypertension and Tachycardia in Spontaneously Hypertensive Rats

BackgroundWe previously showed that the levels of both Giα‐2 and Giα‐3 proteins were augmented in spontaneously hypertensive rats (SHRs) before the onset of hypertension. In addition, intraperitoneal injection of pertussis toxin, which inactivates both Giα proteins, prevented the development of hype...

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Principais autores:	Yousra Ali El‐Basyuni, Yuan Li, Madhu B. Anand‐Srivastava
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2016-10-01
Series:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Assuntos:	antisense Giα‐2 proteins Giα‐3 proteins hypertension oxidative stress tachycardia
Acceso en liña:	https://www.ahajournals.org/doi/10.1161/JAHA.116.004594
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