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Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue

<p>Abstract</p> <p>Background</p> <p>Transmitted HIV-1 clade B or C R5 viruses have been reported to infect macrophages inefficiently, while other studies have described R5 viruses in late disease with either an enhanced macrophage-tropism or carrying envelopes with an increased positive charge and...

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Principais autores: Gonzalez-Perez Maria, O'Connell Olivia, Lin Rongheng, Sullivan W Matthew, Bell Jeanne, Simmonds Peter, Clapham Paul R
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2012-03-01
coleção:Retrovirology
Assuntos:
HIV
Envelope
Macrophage-tropism
CD4
CCR5
Neurotropism
Immune tissue
Brain
Entry
Acesso em linha:http://www.retrovirology.com/content/9/1/20
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