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Thiophene-Linked 1,2,4-Triazoles: Synthesis, Structural Insights and Antimicrobial and Chemotherapeutic Profiles

The reaction of thiophene-2-carbohydrazide <b>1</b> or 5-bromothiophene-2-carbohydrazide <b>2</b> with various haloaryl isothiocyanates and subsequent cyclization by heating in aqueous sodium hydroxide yielded the corresponding 4-haloaryl-5-(thiophen-2-yl or 5-bromothiophen-2-yl)-2,4-dihydro-3<i>H</...

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Hoofdauteurs: Nada A. El-Emam, Mahmoud B. El-Ashmawy, Ahmed A. B. Mohamed, El-Sayed E. Habib, Subbiah Thamotharan, Mohammed S. M. Abdelbaky, Santiago Garcia-Granda, Mohamed A. A. Moustafa
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2024-08-01
Reeks:Pharmaceuticals
Onderwerpen:
1,2,4-triazoles
thiophene
antimicrobial activity
anti-proliferative activity
molecular docking
single-crystal XRD
Online toegang:https://www.mdpi.com/1424-8247/17/9/1123
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