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Disinhibition-Mediated LTP in the Hippocampus is Synapse Specific

Paired pre- and postsynaptic activity in area CA1 of the hippocampus induces long-term inhibitory synaptic plasticity at GABAergic synapses. This pairing-induced GABAergic plasticity weakens synaptic inhibition due to a depolarization of the reversal potential for GABAA receptor-mediated currents (...

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Principais autores: Jake eOrmond, Melanie A Woodin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2011-09-01
Serier:Frontiers in Cellular Neuroscience
Fag:
GABA
KCC2
LTP
synaptic plasticity
chloride (Cl-)
spike-timing dependent plasticity (STDP)
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fncel.2011.00017/full
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