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Microneedle-facilitated Portulaca oleracea L.-derived nanovesicles ameliorate atopic dermatitis by modulating macrophage M1/M2 polarization and inhibiting NF-κB and STING signaling pathways

Clinical management of atopic dermatitis (AD) is challenged by its susceptibility to recurrence, side effects, and high costs. We found that Portulaca oleracea L.-derived nanovesicles (PDNV) exert anti-inflammatory effects by modulating macrophage M1/M2 polarization. These effects were achieved thro...

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Principais autores: Meng Long, Jiaqi Li, Yuecheng Zhu, Hang Ruan, Jing Li, Fanjun Xu, Ruipeng Liu, Tao Yang, Yanqin Shi, Nianping Feng, Yongtai Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-11-01
coleção:Acta Pharmaceutica Sinica B
Assuntos:
Plant-derived nanovesicles
Exosomes
Microneedles
Atopic dermatitis
Portulaca oleracea L.
Transdermal delivery
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211383525005738
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