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Single-cell insights into tumor microenvironment heterogeneity and plasticity: transforming precision therapy in gastrointestinal cancers

Abstract The development and progression of gastrointestinal (GI) cancers not only depend on the malignancy of the tumor cells, but is also defined by the complex and adaptive nature of the tumor microenvironment (TME). The TME in GI cancers exhibits a complex internal structure, typically comprisin...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Jialei Weng, Feng Ju, Zicheng Lyu, Ningbo Fan, Daniel J. Smit, Wenxin Xu, Xiaolin Wu, Philip Becker, Yinan Xu, Michal R. Schweiger, Axel M. Hillmer, Ralf Harwig, Sheraz Gul, Alexander Link, Lydia Meder, Nan Fang, Qiongzhu Dong, Christiane J. Bruns, Ning Ren, Yue Zhao
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2025-11-01
Rangatū:Journal of Experimental & Clinical Cancer Research
Ngā marau:
Gastrointestinal cancers
Single-cell RNA sequencing
Heterogeneity
Plasticity
Tumor microenvironment
Cell subsets
Urunga tuihono:https://doi.org/10.1186/s13046-025-03567-5
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