Coordinate to guard: crosstalk of phosphorylation, sumoylation and ubiquitylation in DNA damage response

Small ubiquitin-like modifier-1/2/3 (SUMO-1/2/3) and ubiquitin share similar structure and utilize analogous machinery for protein lysine conjugation. Although sumoylation and ubiquitylation have distinct functions, they are often tightly associated with each other to fine-tune protein fate in trans...

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Bibliografische Detailangaben

Hauptverfasser:	Ching-Ying eKuo, Christine eShieh, Fei eCai, David Kong Ann
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2012-01-01
Schriftenreihe:	Frontiers in Oncology
Schlagworte:	Phosphorylation Sumoylation ubiquitylation DNA damage response ATM
Online-Zugang:	http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00061/full
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