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Full Profiling of GE81112A, an Underexplored Tetrapeptide Antibiotic with Activity against Gram-Negative Pathogens

ABSTRACT After the first total synthesis combined with structure revision, we performed thorough in vitro and in vivo profiling of the underexplored tetrapeptide GE81112A. From the determination of the biological activity spectrum and physicochemical and early absorption-distribution-metabolism-excr...

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Principais autores: Sören M. M. Schuler, Gerrit Jürjens, Alexander Marker, Ulrike Hemmann, Astrid Rey, Stéphane Yvon, Marjorie Lagrevol, Mohamed Hamiti, Fabian Nguyen, Rolf Hirsch, Christoph Pöverlein, Andreas Vilcinskas, Peter Hammann, Daniel N. Wilson, Michael Mourez, Sebastien Coyne, Armin Bauer
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2023-06-01
Serier:Microbiology Spectrum
Fag:
GE81112A
antibiotic
profiling
Online adgang:https://journals.asm.org/doi/10.1128/spectrum.02247-22
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