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Mst1 overexpression combined with Yap knockdown augments thyroid carcinoma apoptosis via promoting MIEF1-related mitochondrial fission and activating the JNK pathway

Abstract Background Cancer cell viability is strongly modulated by the Hippo pathway, which includes mammalian STE20-like protein kinase 1 (Mst1) and yes-associated protein (Yap). Although the roles of Mst1 and Yap in thyroid carcinoma cell death have been fully addressed, no study has determined wh...

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Principais autores: Xiaoli Zhang, Fei Li, Yeqing Cui, Shuang Liu, Haichen Sun
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-05-01
Serier:Cancer Cell International
Fag:
MDA-T32 cells
Mitochondrial fission
Thyroid cancer
JNK-MIEF1 pathway
Online adgang:http://link.springer.com/article/10.1186/s12935-019-0860-8
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