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Aberrant DNA methylation in ES cells.

Both mouse and human embryonic stem cells can be differentiated in vitro to produce a variety of somatic cell types. Using a new developmental tracing approach, we show that these cells are subject to massive aberrant CpG island de novo methylation that is exacerbated by differentiation in vitro. Bi...

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Principais autores: Guy Ludwig, Deborah Nejman, Merav Hecht, Shari Orlanski, Monther Abu-Remaileh, Ofra Yanuka, Oded Sandler, Amichai Marx, Douglas Roberts, Nissim Benvenisty, Yehudit Bergman, Monica Mendelsohn, Howard Cedar
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2014-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC4031077?pdf=render
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