Intranasal NS1-truncated live attenuated canine influenza vaccine confers superior protection compared to inactivated vaccine in beagles

Abstract Canine influenza virus (CIV) H3N2 continues to circulate among companion animals, posing a zoonotic risk due to its potential for cross-species transmission. However, currently available inactivated vaccines offer limited mucosal immunity and suboptimal protection. Here, we developed a nove...

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Autors principals: Jaehyun Hwang, Sun-Woo Yoon, Eulhae Ga, Jaeseok Choi, Suyun Moon, Eunseo Bae, Hyeongcheol Yun, Dohyeok Yu, Hye Kwon Kim, Jung-Ah Kang, Minjoo Yeom, Jong-Woo Lim, Dae Gwin Jeong, Xing Xie, Daesub Song, Woonsung Na
Format: Artigo
Idioma:Inglês
Publicat: BMC 2025-09-01
Col·lecció:Veterinary Research
Matèries:
Canine influenza virus (H3N2)
live attenuated influenza vaccine (LAIV)
NS1-truncated vaccine
intranasal vaccine
mucosal immunity
beagle dog model
Accés en línia:https://doi.org/10.1186/s13567-025-01624-7
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