Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22
LGI1 is an epilepsy-related gene that encodes a secreted neuronal protein. Here the authors present the crystal structure of LGI1 bound to its receptor ADAM22, which provides structural insights into epilepsy-causing LGI1 mutations and might facilitate the development of novel anti-epilepsy drugs.
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| Autori principali: | , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2018-04-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-018-03947-w |
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