The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.
The cyclic GMP-AMP synthase (cGAS), upon cytosolic DNA stimulation, catalyzes the formation of the second messenger 2'3'-cGAMP, which then binds to stimulator of interferon genes (STING) and activates downstream signaling. It remains to be elucidated how the cGAS enzymatic activity is modulated dyna...
I tiakina i:
| Ngā kaituhi matua: | , , , , , , , , , , , , , , |
|---|---|
| Hōputu: | Artigo |
| Reo: | Inglês |
| I whakaputaina: |
Public Library of Science (PLoS)
2017-03-01
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| Rangatū: | PLoS Pathogens |
| Urunga tuihono: | https://doi.org/10.1371/journal.ppat.1006264 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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