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Predicting the number of lifetime divisions for hematopoietic stem cells from telomere length measurements

Summary: How many times does a typical hematopoietic stem cell (HSC) divide to maintain a daily production of over 1011 blood cells over a human lifetime? It has been predicted that relatively few, slowly dividing HSCs occupy the top of the hematopoietic hierarchy. However, tracking HSCs directly is...

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Bibliografiske detaljer
Principais autores: Cole Boyle, Peter M. Lansdorp, Leah Edelstein-Keshet
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-07-01
Serier:iScience
Fag:
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004223011306
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