Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases

Abstract Background The bcr-abl fusion gene is the pathological origin of chronic myeloid leukemia (CML) and plays a critical role in the resistance of imatinib. Thus, bcr-abl disruption-based novel therapeutic strategy may warrant exploration. In our study, we were surprised to find that the charac...

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Detalhes bibliográficos

Principais autores:	Ningshu Huang, Zhenglan Huang, Miao Gao, Zhenhong Luo, Fangzhu Zhou, Lin Liu, Qing Xiao, Xin Wang, Wenli Feng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-03-01
coleção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	Chronic myeloid leukemia Bcr-abl Zinc finger nucleases Homology-directed repair Oncogenicity
Acesso em linha:	http://link.springer.com/article/10.1186/s13046-018-0732-4
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