Artificial intelligence-, organoid-, and organ-on-chip-powered models to improve pre-clinical animal testing of vaccines and immunotherapeutics: potential, progress, and challenges

Vaccines and immunotherapies against infectious diseases and cancers have been a great success of the medical sciences over the last century. Pre-clinical testing in animal models has played a crucial role in the development of vaccines and immunotherapies, informing subsequent clinical trials. The...

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Autors principals: Elhoucine Elfatimi, Yassir Lekbach, Swayam Prakash, Sweta Karan, Joshua Christian Dorotta, America Garcia, Beverly Sabathini Suoth, Chhaya Maurya, Etinosa Yvette Omorogieva, Sarah Xue Le Ng, Emma Jane Liao, Reilly Andrew Chow, Lbachir BenMohamed
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2025-10-01
Col·lecció:Frontiers in Artificial Intelligence
Matèries:
artificial intelligence—AI
organoid
organ-on-chip
immunotherapeutics
vaccines
infectious diseases
Accés en línia:https://www.frontiersin.org/articles/10.3389/frai.2025.1681106/full
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