Sequence variability of BamA and FadL candidate vaccinogens suggests divergent evolutionary paths of Treponema pallidum outer membrane proteins

ABSTRACT Knowledge of Treponema pallidum subspecies pallidum (TPA) outer membrane protein (OMP) sequence variability is essential for understanding spirochete proliferation within endemic populations as well as the design of a globally effective syphilis vaccine. Our group has identified extracellul...

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Autori principali:	Everton B. Bettin, Farhang Aghakhanian, Christopher M. Hennelly, Wentao Chen, Timothy C. Davenport, Simon T. Hackl, Andre A. Grassmann, Fabio Vargas-Cely, Sebastián Silva, Jonny A. García-Luna, Lady G. Ramirez, Yinbo Jiang, Ligang Yang, Heping Zheng, Bin Yang, Petra Pospíšilová, David Šmajs, Mitch M. Matoga, Irving F. Hoffman, Eduardo López-Medina, Kay Nieselt, M. Anthony Moody, Arlene C. Seña, Juan C. Salazar, Jonathan B. Parr, Melissa J. Caimano, Kelly L. Hawley, Justin D. Radolf
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2025-08-01
Serie:	Journal of Bacteriology
Soggetti:	syphilis outer membrane proteins protein variability whole-genome sequencing vaccines
Accesso online:	https://journals.asm.org/doi/10.1128/jb.00159-25
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