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Machine Learning to Predict Drug-Induced Liver Injury and Its Validation on Failed Drug Candidates in Development

Drug-induced liver injury (DILI) poses a significant challenge for the pharmaceutical industry and regulatory bodies. Despite extensive toxicological research aimed at mitigating DILI risk, the effectiveness of these techniques in predicting DILI in humans remains limited. Consequently, researchers...

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Wedi'i Gadw mewn:
Prif Awduron: Fahad Mostafa, Victoria Howle, Minjun Chen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI AG 2024-05-01
Cyfres:Toxics
Pynciau:
machine learning
drug-induced live injury
liver toxicity
random forest
multilayer perceptron
failed drug candidates
Mynediad Ar-lein:https://www.mdpi.com/2305-6304/12/6/385
Tagiau: Ychwanegu Tag
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