Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene

ABSTRACT Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) and induces tumorigenesis in several mouse models of CRC. However, whether specific mutations induced by ETBF lead to colon tumor formati...

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Главные авторы:	Jawara Allen, Axel Rosendahl Huber, Cayetano Pleguezuelos-Manzano, Jens Puschhof, Shaoguang Wu, Xinqun Wu, Charelle Boot, Aurelia Saftien, Heather M. O’Hagan, Hao Wang, Ruben van Boxtel, Hans Clevers, Cynthia L. Sears
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology 2022-06-01
Серии:	Microbiology Spectrum
Предметы:	Bacteroides cancer colorectal cancer genomics microbes mutational studies
Online-ссылка:	https://journals.asm.org/doi/10.1128/spectrum.01055-22
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