Potentiation of glycine-gated NR1/NR3A NMDA receptors relieves Ca2+-dependent outward rectification

Glycine has diverse functions within the mammalian central nervous system. It inhibits postsynaptic neurons via strychnine-sensitive glycine receptors (GlyRs) and enhances neuronal excitation through co-activation of N-methyl-D-aspartate (NMDA) receptors. Classical Ca2+-permeable NMDA receptors are...

Полное описание

Библиографические подробности

Главные авторы:	Christian Madry, Heinrich Betz, Jörg Geiger, Bodo Laube
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2010-03-01
Серии:	Frontiers in Molecular Neuroscience
Предметы:	voltage block Zn2+ excitatory glycine receptor ligand-binding domain NMDA receptor NR1 antagonist
Online-ссылка:	http://journal.frontiersin.org/Journal/10.3389/fnmol.2010.00006/full
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