DNA-PKcs orchestrates CTLA-4 depletion-induced senescence in cancer cells

Abstract Immune checkpoints such as cytotoxic T-lymphocyte–associated protein 4 (CTLA-4), programmed cell death 1 (PD-1), and programmed cell death ligand 1 (PD-L1) have been targeted in cancer therapy, however, the efficacy of these interventions remains limited. Beyond its immune function on T cel...

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Autores principales:	Je-Jung Lee, Woo Joong Rhee, So Young Kim, Jisun Lee, Su Ful Jung, Jooyeon Oh, In Ho Park, Jeon-Soo Shin
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Publishing Group 2026-02-01
Colección:	Cell Death and Disease
Acceso en línea:	https://doi.org/10.1038/s41419-026-08419-4
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